Pfizer is interested in establishing alliances to develop and/or access:
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Patient cohorts with high quality longitudinal molecular and phenotypic data and/or DNA and appropriately-consented, IRB-approved tissue samples in diseases of interest to Pfizer for
- clinical trials
- data mining
- biomarker studies
- genetic and pharmaco-genomic studies
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Systems Biology/Pharmacology
- Databases with high quality treatment and disease outcomes associated with genetic, as well as molecular (metabolomic, proteomic, transcriptomic, epigenetic, clinical chemistry markers) or functional measures in particular imaging data
- Databases of searchable eQTLs, pQTLs across tissues
- Disease biology guided combination therapy design platforms
- Systems biology approaches and proven in silico tools to evaluate pharmacological perturbation and elucidate mechanisms of in vivo toxicity
- Mining of data for correlation and understanding of causality
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Breakthrough diagnostic technologies that also are highly quantitative, require minimal specimen/ tissue, offer quick turnaround time and can be multiplexed. This will include but not limited to:
- Near-patient Point-of-Care technologies
- Next Generation Sequencing technologies
- Circulating cells
- Circulating and urinary cell-free nucleic acids
- Antigen receptor sequencing
- Microbiome, including virome characterization
- In vivo imaging technologies (including MRI, PET, CT, optical imaging technologies, imaging agents, genetically encoded tags, etc.,) with particular interest in:
- Imaging agents for small and large molecule compound distribution studies
- Imaging agents monitoring physiology mechanisms and disease
- Analytical tools and technologies
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Biospecimen Analysis
- Circulating tumor cell and Nucleic Acid quantification and analysis
- Multiplexed flow cytometry for leukocyte analysis
- Automated IHC for tissue analysis (cancer, safety)
- Advanced ADME — related genotyping
- 3D cell models for safety and efficacy assessment that ideally incorporate genetic diversity
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Physiological Biomarkers
- Technologies adding precision to pain management and treatment in pre-clinical and clinical studies
- EEG-based biomarker for assessment of central pharmacology
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iPS cell resources and technologies to generate iPS cells that may be used to enable Precision Medicine strategies
- Validated cell differentiation protocols
- iPS cells derived from sub populations with specific genotypic/phenotypic data
- Technology to create iPS cells in a rapid and reproducible fashion without insertional approaches