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Senior Scientist - T cell engagers

  • United States - California - La Jolla
Full time
Posted 22 Days Ago
4925489
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Our Purpose

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.
Explore our mission

Our Values

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.
Learn our four core values

Benefits

​​​​​​​Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.
Read about our benefits

Pfizer, We are one

Pfizer, We are one

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies that matter most. The Oncology Research Unit in La Jolla, CA is focused on supporting the execution and diversification of the Oncology Research pipeline and translating discoveries into novel therapeutics. Our team takes a holistic approach to understand the interplay of tumor, stromal, and immune cells in the tumor microenvironment, striving to define the axes of intercellular communication that could be leveraged to generate novel therapeutics. Our T cell biology team is looking for a motivated and creative Senior Scientist to uncover the next generation T cell engagers to change patients’ lives.

What You Will Achieve

As a member of our T cell biology team, you will identify and evaluate novel T cell-targeted approaches in the field of Cancer Immunotherapy. You will advance our pre-clinical drug discovery programs in a fast-paced and highly collaborative team of motivated and scientifically rigorous scientists. You will contribute to study execution, data analysis and coordinate activities across research team to drive program progression. You will be recognized as a scientific contributor at the team and project level. With your knowledge of T cell biology and cancer immunotherapy, you will be an active team member whose decisions impact projects and strategy to deliver novel T cell engagers. Your creativity in developing novel projects and new ideas will be used frequently.

How You Will Achieve It

  • Contribute to discovery research programs up to early clinical development by providing scientific and technical T cell biology expertise.

  • Work in a matrixed environment and collaborate with multiple disciplines to identify and pursue the most promising drug candidates.

  • Support a team of scientists to conceptualize, design, and execute experiments and support target identification/validation, mechanism of action studies, and biomarker identification.

  • Interpret, present, and document experiments as well as preparation of reports.

  • Assist in designing, planning, and executing project strategies to ensure efficient and effective decision-making.

  • Communicate strategy and results accurately and concisely to stakeholders in a multidisciplinary team environment.

  • Publish results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.

Qualifications

  • PhD degree in Immunology or a related discipline.

  • Minimum of 2 years relevant industry immune-oncology drug discovery and development experience.

  • Technical and scientific experience developing multi-specific antibodies targeting T cells.

  • Broad technical and scientific expertise assessing T cell phenotypes and function (flow cytometry, incucyte, MSD, confocal microscopy) in preclinical animal and ex vivo models.

  • Experience contributing to a research program, ideally as biology/ research project lead and experience assisting in designing, planning, and executing biology project strategies.

  • Experience in collaborative research in Oncology drug discovery programs in a fast-paced environment.

  • Strong written and verbal communication skills.

  
 

PHYSICAL/MENTAL REQUIREMENTS

Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Must be willing to work after hours as needed to ensure study integrity.


 


The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.  These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure.  Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act.  Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government.  If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.  This position requires permanent work authorization in the United States.

Research and Development

Breakthroughs that change patients’ lives

Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.

Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:

“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.

“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.

“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.

Our Values

To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.

Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.

Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.

Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.

Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.

Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

  • Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
  • Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
  • Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
  • And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)

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