Director, Analytical Characterization, ADC Discovery

United States - Washington – Bothell

Full time

Posted 16 Days Ago

4924858

ROLE SUMMARY

Pfizer ORU (Oncology Research Unit) is seeking a Director to lead the Bioanalytical team responsible for Large and Small-molecule characterization in our ADC Discovery organization. The Bioanalytical team is an integral part of Protein and Bioanalytical Sciences (PBS) group within Pfizer ORU. This multidisciplinary team is at the forefront of characterizing the small molecules, antibodies, antibody-drug conjugates (ADCs) and novel protein technologies. The team responsibilities include stability testing of new therapeutic compositions, the bioanalytical assessment of ADC payload release, cellular deposition, exploration of new delivery technology formats, and assessment of binding affinity for both small and large molecules. The appointed leader will drive a dynamic and collaborative team, focusing on expanding technological capabilities to enhance the capacity and efficiency of key deliverables, crucial for advancing the discovery of novel ADCs aimed at cancer treatment. As a strategic and operational cornerstone, the team leader will collaborate with other senior members of the ADC Discovery Research Group to build and drive Pfizer's ADC strategy and advance Pfizer's preclinical pipeline.

KEY RESPONSIBILITIES

Lead a team of 6+ scientists including PhD level.
Create and manage sub-team prioritization efforts within the group to ensure optimal portfolio progression and scientific rigor.
Develop the strategies to improve capacity and efficiency of platform technologies through innovation and application of new technologies e.g. automation, platforms, workflows and externalization.
Leverage new technologies and existing bioanalytical approaches to characterize protein biologics and ADC mechanisms of action
Work closely with early Research and Process Sciences departments to balance priorities and ensure efficient transfer of knowledge and processes from Discovery to the Pharmaceutical Sciences team
Represent the team in governance forums and advocate for teams’ visibility
Provide supervision and mentorship, establishing the vision, implementation of new technologies and enabling personal growth of team members
Promote a culture of professionalism and collaboration focused on patient outcomes in alignment with company goals and values

REQUIRED QUALIFICATIONS

Ph.D. in Biochemistry, Chemistry or related discipline
Minimum 7+ years with Ph.D. or 9+ years post MS related oncology or chemistry experience in industry, including technical and scientific experience in drug discovery and preclinical development
Expertise in ADCs, including understanding of drug linker and small molecule biochemical conjugation, and in vitro and in vivo molecule stability characterization
Expertise in protein-protein and small molecule binding kinetics using BLI or SPR technologies
Expertise in analytical method development across for various biotherapeutic modalities.
Deep understanding of antibody binding behavior with antigens and Fc receptors, including FcRn.
Technical expertise in mass spectrometry in both large and small molecules across various vendor platforms
CMC experience in project progression from research to development
Deep experience in building, leading and directly managing teams, capable of giving feedback, coach, mentor, and develop employees
Demonstrated track record in collaborative research in ADC Oncology drug discovery programs with strong business acumen and communication skills
Ability to collaborate across teams and a variety of disciplines to create and communicate scientific strategy and priorities

PREFERRED QUALIFICATIONS

Strong track record of scientific accomplishments in industry as evidenced by publications or other equivalent achievements
Experience getting results through creativity and unique problem solving

Relocation support available

Work Location Assignment: Bothell, Washington

The annual base salary for this position ranges from $161,600.00 to $269,400.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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