Scientist - Antibody Optimization (non- PHD)

United States - Washington – Bothell

Full time

Posted 2 Days Ago

4924654

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.

What You Will Achieve

As a Scientist, you will be at the center of our operations and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be part of Pfizer's Worldwide Research and Development team that employs a multidisciplinary approach to identify and target cancer cell cycle for developing the next generation Oncology therapeutics and therapeutic combinations.

You will contribute to early discovery and protein engineering for the development of novel biotherapeutics. You will be responsible for extensive molecular biology, tissue culture and cell biology benchworks, including vector engineering, Polymerase Chain Reaction (PCR), cloning, cell line engineering and cell-based assay development. You will also contribute to protein/antibody expression and purification, biophysical characterizations and target validation.

With your deep knowledge in the discipline, you will be an active team member who influences at the project team level. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience and consulting others. Your ability to plan will help in preparing short-term work activities on projects. Your creativity in developing novel processes and new ideas will be used frequently.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

Contribute to achievement of goals and influence at the project team level.
Carry out experiments including cell binding, kinetic, internalization and cytotoxic activity, to evaluate bispecific formats and bispecific target pairings.
Evaluate data and provide clear reports that can be shared and transferred to and from cross-functional teams.
Pay attention to detail, strictly adhere to safety protocols, and use knowledge of basic laboratory procedures to advance projects under rapidly shifting priorities and timelines.

Qualifications

Must-Have

Bachelor's Degree
6+ years of experience
Substantial experience with standard molecular biology skills and mammalian cell culture techniques
Experience implementing and executing novel drug combination strategies
Strong interest in computational biology and bioinformatics
Ability to effectively interact and collaborate with other scientists and computational biologists, both within the group and in other groups
Excellent written and oral communication skills

Nice-to-Have

Master's degree and 4+ years of relevant experience
Experience working with antibodies and alternative antibody formats (e.g. bispecific)
Past ADC experience including conjugation and evaluation of ADC activity
Understanding of display technologies such as phage or yeast display
Track record of successful contribution to research projects, preferably utilizing gene editing or screening methodologies

Additional Information:

Work Location Assignment: On Premise
Eligible for Employee Referral
Last Day to Apply: Friday, December 6, 2024

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

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