Senior scientist - Bacterial Immunology

Senior Scientist – Bacterial Immunology (PhD only)

Why Patients Need You

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Pfizer Vaccines Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into vaccines that matter most. You will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class vaccines to patients around the world.

What You Will Achieve

The primary purpose of Senior Scientist – Bacterial Immunology (PhD only) job is to provide expertise and support in assay development and immunology for early-stage bacterial vaccine programs. The incumbent will apply skills in immunology and host-pathogen interactions to design assays and experiments to aid the selection of vaccine candidates and generate preclinical data to validate and support proof of concept for novel vaccine candidates and formulations/platforms (e.g. subunit, polysaccharide conjugate, mRNA vaccines, novel adjuvants). Accordingly, the candidate should have experience with associated cell-based and immunological in vitro assays that measure the host response to the infecting pathogen. Experience in ex vivo assays to monitor and evaluate infection and immune responses in animal models is preferred. The incumbent may also collaborate with microbiologists to answer program critical questions about host-pathogen interactions. A strong focus on hands-on experimental work as individual contributor at the lab bench is expected. In addition to contributing individually, the scientist may supervise the activities of junior colleagues (formally or informally) and lead research projects.

The successful candidate will have a unique opportunity to work with a multidisciplinary team on a wide range of vaccine immunology research projects. Excellent communication skills and the ability to work a multifunctional matrix environment are essential for the success of this candidate. This is an exciting opportunity for candidates with strong critical thinking skills and who wants to work in a robust collaborative environment. The candidate will be expected to conduct experiments in the wet lab, manage laboratory and data analysis responsibilities to achieve team goals.

How You Will Achieve It

• Use knowledge of immunology to develop and execute in vitro assays to measure immune responses to immunization and understand vaccine mechanism of protection (e.g. total antibody binding, functional assays, T-cell assays).

• Development ex vivo assays to support animal model development (e.g. assays to measure biomarkers of infection)

• Provide expertise and hands-on support in immunology and host-pathogen interactions for bacterial vaccine programs.

• Plan and execute complex experiments to further project goals. Research, plan and conduct experiments to evaluate immune responses to vaccination and mechanism of protection.

• Lead collaborations with cross functional groups e.g. in vivo and clinical assay teams.

• Contribute original ideas and participate in project planning for individual and team goals.

• Independently design, develop and characterize serological assays.

• Interpret and summarize experimental data. Research and design experiments to resolve technical problems. Present original data at internal and external scientific meetings.

• Stay current in research tools and emerging approaches to evaluate immune responses to vaccination and host-pathogen interactions by keeping up with relevant literature and attending scientific meetings.

• Maintain laboratory notebook in a detailed and descriptive manner.

• Satisfactorily completes all cGMP/GLP and safety training in conformance with departmental requirements.

• Electronic documentation of lab work in a detailed fashion, summarizing and reporting data in an organized fashion.

• Prepare results for presentation, inclusion in technical reports, and for publication in peer-reviewed scientific journals.

• The incumbent has training on required Policies, Practices, and Procedures needed to support their work. Other technical training on job-specific tasks may be required.

Must have

• PhD in immunology, microbiology, or host-pathogen interactions with a minimum of 2 years of relevant post-graduate experience with demonstrated data analysis skills and strong publication record is required.

• Hands on experience with in vitro assays to measure immune responses: IgG binding assays, opsonophagocytic assays, neutralization assays.

• Knowledge of T-cell immunology and experience running relevant assays, including experience with multicolour flow cytometry and FACS sorting to measure and analyze immune responses. Ability to effectively manage, organize and prioritize multiple projects and meet deadlines.

• Excellent critical thinking, communication and organizational skills.

• The position requires strong analytical, quantitative and leadership skills in addition to exceptional multi-tasking capabilities and organizational skills.

• Incumbent must be able to effectively communicate complex ideas and concepts through excellent writing, oral presentation and teaching skills.

• Proficiency with Microsoft Office applications and relevant scientific software, including graphing/statistical analysis tools is required.

Nice to have

• Knowledge of human and murine immunology.

• Experience with animal models of infection and ex vivo assays to measure biomarkers of infection.

• Hands on experience with development of serological assays.

• Experience designing and interpreting experiments using T- and B-cell receptor sequencing, single cell RNA-seq.

PHYSICAL/MENTAL REQUIREMENTS

• Lifting, sitting, standing, walking, bending

• Ability to perform mathematical calculations and ability to perform complex data analysis

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

• May require occasional non-standard work schedule e.g. dependent on experiments

Other Job Details

• Work Location Assignment: On Premise

• Relocation support available

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Research and Development