Scientist, Proteomics (NON-PHD)

United States - California - La Jolla

Full time

Posted 5 Days Ago

4917518

ROLE SUMMARY

At Pfizer we deliver breakthroughs that change patients’ lives. In La Jolla, we are dedicated to the development of oncology agents that disrupt cancer biology or redirect the immune system against cancer cells.

The Systems Biology team plays a vital role in this mission through enabling the discovery and molecular understanding of antibody-drug conjugates and small-molecule therapeutics. We are seeking a researcher with general cell biology and mass spectrometry laboratory experience.

As a Proteomics Scientist within the Systems Biology team, your research will drive a deeper understanding of drug targets through profiling tumor associated antigen (TAA) abundance in normal and tumor tissues, assessing proteome specificity degraders and degrader-antibody conjugates, and investigation of drug mechanism-of-action through mapping interactomes and post-translational modifications. The successful candidate will participate on project teams, providing insight and technical expertise required for project progression. The individual will also work closely with the Medicinal Chemistry, Protein Engineering, and Oncology Biology groups to innovate and develop the next-generation of therapies.

ROLE RESPONSIBILITIES

Prepare samples for from cell lines and tissues for proteomic studies
Develop and optimize protocols. Analyze and summarize results from western blot and mass spectrometry studies.
Participate on multi-disciplinary project teams, including developing experimental plans and communication of results
Learn and apply state-of-the-art chemical biology technologies for target engagement and interactome mapping.
Advance expertise and group technologies through participation in working groups, conferences, and training courses

BASIC QUALIFICATIONS

B.S. degree with 5+ years’ research experience in the fields of biology, biochemistry, or similar.
Experience with mammalian cell culture and mass spectrometry.
Experience with gel electrophoresis, western blotting/WES, plate-based assays, and/or protein quantification.
Excellent record keeping and attention to detail.
The ability to work in a fast-paced matrix-team environment.
Strong verbal, written communication, and interpersonal skills.

PREFERRED QUALIFICATIONS

M.S. degree with 3+ years' research experience
Prior proteomics experience with an TOF or Orbitrap utilizing DIA with label-free quantitation, or DDA with TMT.
Experience with mass spec maintenance and QC, automated sample preparation (Bravo AssayMAP, Kingfisher), global proteomic profiling, immunoprecipitation mass spectrometry (IP-MS), and enrichment proteomics (surface, membrane, phosphoproteomics).
Contributions on scientific publications
Familiarity with drug discovery and oncology

Additional Information:

Eligible for Employee Referral
Work Location Assignment: On Premise
Last Day to Apply: September 13, 2024

The annual base salary for this position ranges from $74,900.00 to $124,800.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 7.5% of the base salary. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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