Senior Scientist - Cancer Cell Biology

United States - California - La Jolla

Full time

Posted 9 Days Ago

4915857

Our Purpose

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Explore our mission

Our Values

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Learn our four core values

Benefits

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Read about our benefits

Pfizer, We are one

WHY PATIENTS NEED YOU

Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose where we translate science and technologies into the therapies and vaccines that matter most. Whether you are in discovery, ensuring drug safety and efficacy or supporting clinical trials, you will be a key contributor to our mission of bringing best in class medicines to patients around the world.

WHAT YOU WILL ACHIEVE

The Pfizer Oncology Research Unit (ORU) is working to change the trajectory of cancer by translating breakthrough discoveries in cancer research into the best medicines imaginable for patients.

The Oncogene & Cancer Vulnerabilities (O&CV) group, within Pfizer’s Cancer Cell Biology division, is focused on applying the latest scientific knowledge and innovative approaches to discover truly transformational therapies for patients. O&CV supports small molecule cancer drug discovery and development all the way from target discovery and validation through to clinic entry as biology leaders.

The applicant will be an integral part of our collective efforts to discover and target oncogenic drivers as well as tumor evolution networks to overcome adaptive and acquired resistance mechanisms to small molecule therapies. The applicant will work in a lab-based setting and carry-out molecular and cellular based assays, including functional genomic studies and data analysis; employ critical thinking to design and interpret experiments and communicate research findings to mentors and the wider O&CV team. As the applicant integrates data from across different divisions they will gain exposure to the broad Pfizer organization, learn from collaborations with cross-functional teams and be part of a culture that embraces scientific excellence and personal development.

HOW YOU WILL ACHIEVE IT

Lead from the bench - Design, execute and analyze experiments to address the basic and translational biology of novel drug targets, their molecular pathways, and their connection to human disease.
Design, execute and analyze experiments to address the adaptive and acquired resistance nodes and networks of small molecules targeting oncogenic signaling pathways to inform mitigation strategies for these disease states.
Strong attention to detail in experimental design, execution, data integration and interpretation.
Actively lead in scientific discussions and have deep knowledge of publications on relevant research themes.
Effectively communicate and present research findings to the OC&V and project teams.
Take initiative to collaborate with colleagues within and across departments to drive projects forward.
Contribute to a culture that values teamwork, collegiality, accountability, and continued learning and growth.

QUALIFICATIONS

Must-Have

Ph.D. in Cancer Cell Biology, or a related field, with >2-years of relevant post-doctoral experience in industry or academia.
Track record of independent research evidenced by at least 1 first author publication in reputable peer-reviewed journal.
Track record of independently lead research evidenced by oral and poster presentations at internationally recognized conference series.
Track record of collaborative research evidenced by further co-author publications in reputable peer-reviewed journals.
Research experience in areas of Cancer Cell Biology, such as Oncogenic Cell Signaling, Tumor Plasticity and Heterogeneity or Adaptive networks and Acquired resistance to small molecule inhibitors, molecular glues.
Strong proficiency with foundational Cell and Molecular Biology techniques (eg: Construct Design, Lentiviral Generation, Stable Cell line Generation, 2D-adhered and 3D-Spheroid Proliferation assays, Western blots, QPCR etc).
Strong proficiency in functional genomic and protein interrogation methods (eg: CRISPR, DTAG, etc).
Ability to query oncology databases like cBioportal, TCGA, DepMap, Project Score etc
Excellent organization and planning ability, outstanding verbal and written communication skills, and strong intrinsic motivation to deliver breakthrough therapies for patients.

Nice-to-Have

Broad knowledge across major oncogenic drivers/ signaling pathways.
Experience working with large multi-OMIC data sets eg. Phosphoproteome, RNA Seq, Whole Exome Seq and Single-cell seq data sets.
Computational experience using R-programing language for interpretation of large data sets and figure generation.

Additional Information:

Relocation support available
Eligible for Employee Referral
Work Location Assignment: On Premise
Last Day to Apply: July 22, 2024

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

Breakthroughs that change patients’ lives

Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.

Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:

“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.

“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.

“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.

Our Values

To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.

Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.

Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.

Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.

Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.

Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)

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