Associate Research Fellow - Translational Modeling and Simulation

United States - California - La Jolla
United States - Washington – Bothell

Full time

Posted 4 Days Ago

4914027

Our Purpose

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

Explore our mission

Our Values

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Learn our four core values

Pfizer Research & Development

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Benefits

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Read about our benefits

Pfizer, We are one

ROLE SUMMARY

The successful candidate will join the Translational Modeling and Simulation (TMS) team within Pfizer’s Department of Pharmacokinetics, Dynamics, and Metabolism (PDM). As a core member of multidisciplinary project teams, the candidate will leverage principles and practices of quantitative translational pharmacology (PKPD, PBPK, QSP) to influence decision making from project ideation through early clinical development for both biologic and small molecule modalities. Management and mentorship of junior modeling scientists will be expected with an emphasis on support of the oncology portfolio, and a particular focus on antibody-drug conjugates (ADCs). Opportunities in other therapeutic areas such as immunology and inflammation, metabolic diseases, and infectious diseases may be possible.

Responsibilities:

Work closely with multidisciplinary project teams to develop and implement mechanistic mathematical models of pharmacology to aid in target selection, target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, quantification of exposure-response relationships, biomarker characterization and early clinical trial design
Manage at least one junior colleague in oncology modeling and simulation
Collaborate with research biology in the development of in-vitro assays and in-vivo models to generate data that inform preclinical-to-clinical translational PKPD models
Provide expert support to project teams to design, execute and interpret quantitative pharmacology studies
Partner with colleagues in Clinical Pharmacology and Pharmacometrics to develop end-to-end alignment in model-informed drug development (MIDD) plans and to collectively advance the science and impact of mechanistic modeling and simulation.
Network as appropriate with global experts in the department and other groups to share learnings and enhance consistency in best practices across sites, disease areas, and interventional modalities
Keep up to date with emerging literature in the area of mechanistic modeling and simulation sciences
Continue to build a personal track record of publication in the area of PKPD modeling and simulation and contribute to PDM’s external publication/presentation goals consistent with our sustained investments in the area of modeling and simulation
Up to 25% travel may be required.

Basic Qualifications:

Ph.D. degree or equivalent experience in pharmaceutical sciences, systems pharmacology, pharmacometrics, engineering, mathematics, physics or similar disciplines where modeling and simulation is emphasized.
10+ years of pharmaceutical industry or related experience in developing and applying mechanism based quantitative pharmacology models (e.g. PBPK, PKPD, QSP) to guide project teams from early discovery to early clinical development
Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
Ability to effectively translate/condense/summarize outcomes of modeling and simulation analyses into useable information for multidisciplinary project teams
Good team player and communicator with ability to guide efficient communication of modeling and non-modeling concepts to leadership
Ability to work with on-site and remote colleagues
Good listener and ability to effectively interact with colleagues and leadership with a variety of backgrounds
Keen to interact as a modeling and simulation expert with matrix project teams working closely with within PDM as well as biology, protein engineering, chemistry, safety and clinical scientists
Strong belief that modeling and simulation can have a significant positive impact on research projects
In depth, hands-on knowledge of the state-of-the-art modeling and simulation software with (NONMEM, MATLAB, Monolix, Berkeley-Madonna, R or comparable applications)
Ability to learn new areas of biological sciences and build on a solid foundation of quantitative skills to develop mechanistically relevant PKPD models
Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of PKPD modeling and simulation
Motivated to develop a career as a hands-on, technical modeling and simulation expert in a preclinical drug discovery environment
Committed to sharing technical expertise and the development of self and others

Preferred Qualifications:

Experience in working in the oncology disease area with a focus on ADCs
Familiarity with novel biotherapeutic modalities (bispecifics, Fc-fusions and other targeting agents)
Familiarity with dispositional and pharmacological aspects of both small molecules and biologics.
Prior experience in managing technical experts in modeling and simulation in a pharmaceutical industry setting
Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers, develop and coach others, oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.

PHYSICAL/MENTAL REQUIREMENTS

Ability to perform advanced mathematical and logic calculations

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Up to 25% travel time may be required.

Work Location Assignment: On Premise

Relocation support available

The annual base salary for this position ranges from $149,200.00 to $248,600.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 20.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

Breakthroughs that change patients’ lives

Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.

Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:

“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.

“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.

“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.

Our Values

To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.

Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.

Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.

Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.

Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.

Pfizer Research & Development

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

With an unwavering commitment to innovation, we use a multidisciplinary approach that blends scientific expertise, cutting-edge technologies, and strategic collaborations, igniting a powerful engine that propels groundbreaking discoveries into life-saving treatments for patients in need.

Through our relentless pursuit of progress, we envision a future where cutting-edge medicines pave the way to healthier, happier lives worldwide.

Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)

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