Immunogenicity Principal Scientist

United States - Massachusetts - Andover

Full time

Posted 3 Days Ago

4912567

Our Purpose

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.

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Our Values

To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

Learn our four core values

Pfizer Research & Development

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

Benefits

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.

Read about our benefits

Pfizer, We are one

What You Will Achieve

The Immunogenicity Sciences Group within the Pharmacokinetics, Dynamics, and Metabolism (PDM) Department of Pfizer’s Discovery and Early Development division is an industry-leading team whose mission is to identify key risks associated with unwanted clinical immunogenicity and influence drug design to mitigate those risks.

We are currently seeking an experienced immunogenicity scientist to join this highly innovative team and collaborate with key stakeholders across Pfizer’s Research and Development, including Protein Engineering, Clinical Pharmacology, Drug Safety and Pharmaceutical Sciences. The Principal Scientist role will report to the Immunogenicity Sciences Lead and its core functions are the management of a team of lab-based scientists in their pivotal role in drug design and, drive the establishment of novel approaches to support immunogenicity risk assessment and mitigation strategies of Pfizer’s diverse biologics portfolio.

This unique opportunity will immerse the successful candidate in a diverse array of biotherapeutics modalities being designed and developed to meet the needs of patients across Oncology, Inflammation and Immunology, Internal Medicine and Anti-infective disease areas. The successful candidate will drive advancement of our immunogenicity risk mitigation capabilities through scientific leadership, and application of fundamental immunology sciences to further improve the efficacy and safety of our biologics.

How You Will Achieve It

Design ad-hoc immunogenicity risk identification and mitigation strategies for Pfizer’s biologic portfolio across all disease areas and modalities, oversee execution, data interpretation and delivery to stake holders

Closely collaborate with Pfizer’s BioMedicine Design protein engineers and Research Units Team to enable the development of robust immunogenicity mitigation strategies in keeping with project objectives and timelines
Lead a team of scientists to execute de-risking strategies by applying in silico and in vitro tools to deliver high quality actionable data, navigate change of priorities, program accelerations and implementation of innovation
Identify talent development opportunities to support growth and career progression of team members
Safeguard diversity, equity and inclusion
Actively pursue innovation to improve assay suitability, quality, efficiency, and cost effectiveness
Identify gaps and investigate novel approaches or technologies to advance, improve or optimize scientific practices and procedures in immunogenicity risk assessment and mitigation
Represent the Immunogenicity Sciences group at Projects Teams meetings from discovery through early clinical development
Guide and support project Teams in the writing of Integrated Summary of Immunogenicity and other immunogenicity reports

Contributes to a change-agile, high performing culture of innovation, impact, trust, accountability, and mutual respect in a fast-paced matrix environment
Demonstrate our values and behaviors of Excellence, Courage, Equity and Joy.
Exemplify achievements through publications and external communications

Qualifications

Must-Have

PhD with +4 years of industry experience in drug discovery and development
MS with 9+ years of industry experience in drug discovery and development
Recognized expertise in immunogenicity risk assessment of biologics
Track record of scientific achievement in the field of immunology and immunogenicity
Understanding of perturbations of the immune system in diseases as diverse as cancer and auto-inflammation
Demonstrated success in team management, in particular lab-based scientists
Extensive practical experience of project liaison achieving results in a complex matrix environment
Proven track record in project management
Outstanding interpersonal and communication skills
Track record in publishing own work and through collaborations

Technical Skill Requirements

Core expertise & formal education in applied Immunology; displays significant knowledge of the fundamental relationships between innate and adaptive immunity with relevant diseases such as autoimmunity and oncology
Extensive understanding of clinical implications associated with unwanted immune cellular and humoral responses
Broad experience with state-of-the-art immunogenicity risk assessment tools and analytical platforms, with direct experience in assay design, execution, analysis, interpretation, and application to drug design
Solid familiarity with format, pharmacology, and immunogenicity of biologics
Significant knowledge of immunogenicity monitoring and mitigation
Collaborative skills and effective influencing/partnering skills in a complex, multi-discipline organization
Understanding of opportunities and challenges related to translation of in vitro and in silico models
Lead author or a co-author on internal/external publications and posters
Direct experience in interacting with external organizations, including academics and CROs

Behavioral Competencies

Outstanding interpersonal and communication skills.
High degree of self-awareness
Ability to excel in a collaborative, fast paced and dynamic environment.
Strong leadership in building and maintaining high performing culture of innovation, execution, impact, trust, change agility, accountability, and mutual respect withing the group and in all interactions outside the group
Strong adaptability to changing work assignments and priorities
Grows others; acknowledges contributions across the team
Able to identify opportunities for continuous improvements and lead implementation

PHYSICAL/MENTAL REQUIREMENTS

Ability to work in a biological safety cabinet and perform complex data analysis

Work Location Assignment: On Premise

The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development

Breakthroughs that change patients’ lives

Research confirms what intuition tells us: that purpose-driven companies perform better, are more innovative, attract and retain the best people, and know how to unleash the power of those people. Pfizer’s purpose—Breakthroughs that change patients' lives—fuels everything we do and reflects our passion for building on our legacy as one of the greatest contributors of good to the world.

Each word in our purpose has meaning and reflects the value we strive to bring to patients and society:

“Breakthroughs” - These are the innovations, scientific and commercial, that we seek to deliver every day. All colleagues, regardless of role, level or location, strive for breakthroughs every day.

“Change” - We want to do more than simply improve patients’ medical conditions; we want to dramatically change their lives for the better.

“Patients’ lives” - We consider not only patients, but everyone they touch—including their families, caregivers, and friends—and everything they love to do. It’s an intentionally holistic view.

Our purpose ensures that patients remain at the center of all we do. We live our purpose by sourcing the best science in the world; partnering with others in the healthcare system to improve access to our medicines; using digital technologies to enhance our drug discovery and development, as well as patient outcomes; and leading the conversation to advocate for pro-innovation/pro-patient policies.

Every decision we make and every action we take is done with the patient in mind—and to nurture an environment where breakthroughs can thrive.

Our Values

To fully realize Pfizer’s purpose, we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.

The “how” is represented by four simple, powerful values—courage, excellence, equity, and joy—that define our company and our culture.

Courage: Breakthroughs start by challenging convention, especially in the face of uncertainty or adversity. This happens when we think big, speak up, and are decisive.

Excellence: We can only change patients’ lives when we perform at our best together. This happens when we focus on what matters, agree who does what, and measure our outcomes.

Equity: We believe that every person deserves to be seen, heard, and cared for. This happens when we are inclusive, act with integrity, and reduce healthcare disparities.

Joy: We give ourselves to our work, but it also gives to us. We find joy when we take pride, recognize one another, and have fun.

Pfizer Research & Development

Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.

With an unwavering commitment to innovation, we use a multidisciplinary approach that blends scientific expertise, cutting-edge technologies, and strategic collaborations, igniting a powerful engine that propels groundbreaking discoveries into life-saving treatments for patients in need.

Through our relentless pursuit of progress, we envision a future where cutting-edge medicines pave the way to healthier, happier lives worldwide.

Benefits at Pfizer

Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.

Our Competitive Benefits Programs help our colleagues by:

Promoting Health and Wellness to help colleagues maintain and improve their physical and mental wellbeing. Pfizer offerings include health and disability insurance, preventative health programs, medical screenings, free or reduced-cost vaccinations, discounts on Pfizer products, mental health support, nutrition and fitness counseling and more.
Strengthening Colleagues’ Financial Security by providing company contributions to retirement plans, life insurance and financial planning education to help colleagues achieve their financial goals.
Providing Benefits and Time off for the Moments that Matter to ensure Pfizer colleagues have the time away from the office to recharge, recover and return to work as the best version of themselves. Vacation, Holiday time and Sick time are just the beginning, with a 12 week parental leave policy for both parents of a new born, 10 day of caregiver leave for those times when your family needs you whether it’s a child, spouse or parent, bereavement leave, and additional country-specific programs.
And so much more, depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

For U.S. based jobs, view an overview of Pfizer’s U.S. benefits program (opens in a new window)

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